Rob Morrow stars as FBI agent Don Eppes, who recruits his mathematical genius brother, Charlie (David Krumholtz), to help the Bureau solve a wide range of challenging crimes in Los Angeles. From two very different perspectives, the brothers take on the most confounding criminal cases, aided by Don's partner, Terry Lake (Sabrina Lloyd), and new FBI recruit David Sinclair (Alimi Ballard). Although their father, Alan (Judd Hirsch), is pleased to see his sons working together, he fears their competitive nature will lead to trouble. Charlie's colleague, physicist Dr. Larry Fleinhardt (Peter MacNicol), urges Charlie to focus more on his university studies than on FBI business. Inspired by actual events, NUMB3RS depicts how the confluence of police work and mathematics provides unexpected revelations and answers to the most perplexing criminal questions.