Dan Castellaneta .... Homer Simpson/Grampa/Barney Gumble/Krusty the Klown/Groundskeeper Willie/Mayor Quimby/Hans Moleman/Sideshow Mel/Others (voice)
Julie Kavner .... Marge Simpson/Patty & Selma Bouvier/Others (voice)
Nancy Cartwright .... Bart Simpson/Nelson Muntz/Todd Flanders/Ralph Wiggum/Kearney/Others (voice)
Yeardley Smith .... Lisa Simpson (voice)
Hank Azaria .... Moe Szyslak/Chief Wiggum/Apu/Comic Book Guy/Cletus/Prof. Frink/Others (voice)
Harry Shearer .... Montgomery Burns/Waylon Smithers/Ned Flanders/Kent Brockman/Rev. Lovejoy/Principal Skinner/Dr. Hibbert/Rainer Wolfcastle/Others (voice)
Marcia Wallace .... Edna Krabappel (1990-) (voice)
Phil Hartman .... Lionel Hutz/Troy McClure (1991-1998) (voice)
Tress MacNeille .... Jimbo Jones/Agnes Skinner/Others (voice)
Pamela Hayden .... Milhouse Van Houten/Rod Flanders/Others (voice)
Maggie Roswell .... Maude Flanders/Helen Lovejoy/Others (1990-1999, 2002-) (voice)
Russi Taylor .... Martin Prince/Others (1990-) (voice)
Doris Grau .... Lunchlady Doris (1989-1996) (voice)
Karl Wiedergott .... Additional Voices (1998-) (voice)
Marcia Mitzman Gaven .... Maude Flanders/Helen Lovejoy/Others (1999-2002) (voice)